It must be strongly stated that the use of metal based anti-seize compounds in general is not recommended.
There are two issues to consider:
- Under heat and pressure, the metals in the compound can adhere to the flange surface, causing distortion of the flange and/or fill in the serrations. After a period of time, when this condition has been allowed to progress, no amount of additional torque will allow the gasket to seal.
- Anti-seize lubricates the gasket. This isn't a problem until gasket compression is lost for some reason. Then the lubricated gasket can either be extruded, or forced out of the flange by the internal pressure. Here the friction created by the flange serrations play a role.